Tyrosine-protein phosphatase non-receptor type 9 (PTPN9)

Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) is a cytoplasmic member of the protein tyrosine phosphatase family, functioning as an enzyme that removes phosphate groups from the tyrosine residues of specific proteins. PTPN9 is involved in regulating key cellular processes such as cell growth, differentiation, cell cycle, apoptosis, and angiogenesis. It acts as a negative regulator of various signaling pathways, including VEGF and STAT3, playing roles in both physiological processes like neovascularization and pathological contexts such as cancer progression and ischemic retinopathies. PTPN9 dysregulation is implicated in multiple cancer types, sometimes acting as a tumor suppressor; its specific molecular activities include the regulation of cell proliferation and suppression of pro-angiogenic signaling in response to stress or injury.

Other names

MEG2PTPMEG2protein tyrosine phosphatase non-receptor type 9protein-tyrosine phosphatase-9PTP-MEG2

Dephosphorylation of key signaling molecules including STAT3, VEGF receptor 2 (VEGFR2), nerve growth factor receptor TrkA, insulin receptors