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Target intelligence / Profile preview
Tyrosine-protein phosphatase YopH (YopH)
- Target
- YopH
- Molecular classification
- Enzyme, Protein tyrosine phosphatase
01
Overview
Tyrosine-protein phosphatase YopH is a highly active protein tyrosine phosphatase produced by pathogenic Yersinia species. It is essential for bacterial virulence, disrupting host immune responses during infection by dephosphorylating key signaling molecules in immune cells, thereby inhibiting phagocytosis, blocking calcium fluxes, suppressing cytokine production, and promoting apoptosis of host cells. YopH is a target for therapeutic intervention to combat Yersinia infections.
02
Mechanism of action
Inhibiting YopH activity to restore immune cell function.
03
Biological functions
DephosphorylationImmune response suppressionSignal transduction modulationRegulation of cell adhesionAnti-phagocytosisModulation of calcium-dependent activation pathways
04
Disease associations
InfectionYersiniosisPlague
05
Safety considerations
Off-target effects of YopH inhibitors on host phosphatases.Potential for immune dysregulation if YopH inhibition is excessive.
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