U6 small nuclear RNA 9 (RNU6-9)

U6 small nuclear RNA 9 (RNU6-9) encodes a variant of U6 snRNA, a non-coding RNA critical for the function of the spliceosome—the molecular machine responsible for removing introns from precursor messenger RNA in eukaryotic cells[5][1][3]. U6 snRNA is highly conserved and present in multiple gene copies in vertebrates; RNU6-9 is one such copy[1]. U6 snRNA, together with U1, U2, U4, and U5 snRNAs, and numerous proteins, forms small nuclear ribonucleoproteins (snRNPs) that catalyze the two transesterification steps of splicing[5]. U6 snRNA directly participates at the catalytic core of the spliceosome, binding with other snRNAs and proteins, and base pairing to intron splice sites[5][1]. While dysregulation of U6 snRNA has been observed in disease models, particularly infectious or cancerous states, it is not a classical drug target nor is its modulation currently used clinically[4][5].

Other names

U6 Small Nuclear 9RNU6-9U6-9