U6 snRNA-associated Sm-like protein LSm8 (LSm8)

U6 snRNA-associated Sm-like protein LSm8 (LSM8) is an RNA-binding protein encoded by the *LSM8* gene, forming part of the LSm family[1][3][4]. The protein adopts a closed barrel structure composed of five anti-parallel beta strands and an alpha helix[1][3]. LSm8 partners with six paralogous proteins (LSm2–7) to form a heteroheptameric ring, which specifically binds to the 3'-end of U6 small nuclear RNA (snRNA), playing a crucial role in RNA maturation and stabilization within the nucleus[1][2][3]. This complex is essential for efficient pre-mRNA splicing, acting in the formation and function of the spliceosome, especially the U4/U6-U5 tri-snRNP and B complex[1][3][4]. The *LSM8* gene is evolutionarily conserved, with homologs in yeast and humans. While it is implicated in diseases such as poikiloderma with neutropenia and retinitis pigmentosa, there is currently no evidence supporting its role as a direct therapeutic target or as a biomarker[3]. LSm8 is primarily classified as an RNA-binding protein involved in fundamental RNA processing activities rather than as a receptor, enzyme, transporter, or other classic therapeutic target[1][3][4][5].

Other names

LSM8 homolog, U6 small nuclear RNA associatedU6 snRNA-associated Sm-like protein LSm8YJR022WNAA38LSM8 U6 small nuclear RNA associatedMAK31-like proteinN-alpha-acetyltransferase 38NatC auxiliary subunitLSM8 Homolog, U6 Small Nuclear RNA Associated (S. cerevisiae)[3]

No mechanism of action for drugs targeting this molecule, as it is not a therapeutic target[1][3][5]