U7 small nuclear RNA 93 pseudogene (RNU7-93P)

RNU7-93P (“RNA, U7 small nuclear 93 pseudogene”) is an annotated pseudogene corresponding to the U7 small nuclear RNA gene family[3][4]. Functional U7 snRNA, a component of U7 small nuclear ribonucleoprotein (snRNP), is essential for 3’ end processing of histone pre-mRNA in metazoans[1][3][4]. Pseudogenes like RNU7-93P are highly divergent, usually not transcribed or translated into functional molecules, and exhibit no defined biological role. In the context of drug discovery or therapeutic targeting, pseudogenes are considered non-targets unless exceptional evidence arises. While many variant U7 snRNA-like sequences and pseudogenes are present in mammalian genomes, only the bona fide U7 snRNA gene is functionally relevant in histone mRNA processing[3][4]. Key distinctions: - Functional U7 snRNA is critical in histone mRNA maturation and is a non-coding RNA classified with small nuclear RNAs[1][3][4]. - RNU7-93P is a pseudogene, meaning it is a non-functional genomic locus derived from U7 snRNA gene duplication or retrotransposition events in primate genomes[3][4]. - Only the true U7 small nuclear RNA is experimentally validated in biological pathway roles; pseudogenes like RNU7-93P lack such validation[3][4].

Other names

RNA, U7 small nuclear 93 pseudogeneRNU7-93P