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UBAC2 antisense RNA 1 (UBAC2-AS1)

Target
UBAC2-AS1
Molecular classification
Long non-coding RNA (lncRNA), Antisense RNA, Non-protein coding RNA
01

Overview

UBAC2 antisense RNA 1 (UBAC2-AS1) is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the UBAC2 gene locus on chromosome 13q32.3[2][3][8][9]. As a non-coding RNA, it does not produce a protein product. UBAC2-AS1 is implicated in the regulation of gene expression at the RNA level, possibly by binding target RNA sequences or interacting with protein partners[6]. UBAC2-AS1 has been identified as a potential therapeutic target and prognostic biomarker in several cancers, including clear cell kidney carcinoma[7]. Its dysregulation has been associated with cancer cell proliferation and survival, possibly through mechanisms involving competing endogenous RNA networks and co-expression with oncogenic or tumor-suppressive factors[7]. It has also been linked to lip cancer and glioma susceptibility[3]. The specific molecular partners and pathways remain under exploration, but its regulatory function and disease associations have been reproducibly observed in multiple studies[7][3][6]. No direct drug interactions or targeted therapeutic agents have been reported to date.

Other names
UBAC2-AS1UBAC2 antisense RNA 1 (non-protein coding)UBAC2 antisense RNA 1lncRNA UBAC2-AS1
02

Biological functions

Regulation of gene expressionCompeting endogenous RNAPotential involvement in adipogenesisRegulation of cell proliferationRegulation of apoptosis
03

Disease associations

Cancer (including clear cell kidney carcinoma, lip cancer, glioma)Potential role in other malignancies
04

Biomarkers

Prognostic biomarker for clear cell kidney carcinoma[7]

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