UBE2I antisense RNA 1 (UBE2I-AS1)

UBE2I antisense RNA 1 (UBE2I-AS1) is a long non-coding RNA transcribed antisense to the UBE2I gene, which encodes the SUMO-conjugating enzyme UBE2I (also known as UBC9)[4][6]. Long non-coding RNAs like UBE2I-AS1 may regulate gene expression through a variety of molecular mechanisms, including acting as competing endogenous RNAs, modulating the stability of mRNAs, or influencing chromatin state, but the specific biological function, disease relevance, and druggability of UBE2I-AS1 remain largely uncharacterized[3]. UBE2I-AS1 should not be confused with its neighboring gene, UBE2I, which encodes a well-characterized protein involved in SUMOylation and has been implicated in cancer and other diseases[2][4][6]. There is currently no evidence that UBE2I-AS1 itself is used as a therapeutic target, biomarker, or safety marker. Note: The protein-coding gene UBE2I (sometimes called UBC9) is a therapeutic target, but UBE2I-AS1 is not. Most published data focus on UBE2I, not its antisense RNA. Antisense lncRNAs like UBE2I-AS1 may regulate the expression of their sense partner, but their therapeutic targeting and biological clarity are currently extremely limited in the literature[3][4][6].

Other names

RP11-616M22.7UBE2I-AS1