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Target intelligence / Profile preview
Ubinuclein-2 (UBN2)
- Target
- UBN2
- Molecular classification
- Chromatin-associated protein, Histone chaperone, HIRA complex subunit, Epigenetic regulator
01
Overview
Ubinuclein-2 is a nuclear protein localized to the nucleoplasm, belonging to the ubinuclein family. It is a key component of the HIRA complex that regulates chromatin remodeling, histone variant integration, and gene silencing in mammals. UBN2's role in the balance between apoptosis and autophagy is most pronounced in the context of acute myeloid leukemia, where its expression correlates inversely with tumor-suppressive microRNAs and influences patient prognosis. In mouse models, loss of Ubn2 causes sex-specific lethality due to defects in X chromosome inactivation, underscoring its essential role in gene dosage compensation and early embryonic viability. UBN2 interacts with other chromatin modifiers and transcriptional regulators and is being investigated as a potential therapeutic target in oncology and developmental biology[1][3].
- Other names
- Ubinuclein-2UBN2KIAA2030FLJ25778ubinuclein-2UBN2 (GeneCards)
02
Mechanism of action
Modulation of chromatin state via histone H3.3 deposition; Regulation of autophagy/apoptosis signaling (inhibition by chloroquine counters UBN2-mediated apoptosis in AML)
03
Biological functions
Chromatin organizationHistone H3.3 depositionGene silencing, especially X chromosome inactivation (XCI)Regulation of apoptosis and autophagyCell proliferation (especially in AML)
04
Disease associations
Cancer (linked to AML)Developmental disorders (essential for early mouse development, especially in females)
05
Safety considerations
No established safety concerns for drug targeting; functional knockout in mice shows sex-specific embryonic lethality and compromised XCI, indicating possible developmental risks.
06
Interacting drugs
chloroquine
07
Biomarkers
None clinically used
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