Ubiquinol-cytochrome c reductase binding protein (UQCRB)

Ubiquinol-cytochrome c reductase binding protein (UQCRB) is a nuclear-encoded, approximately 14 kDa subunit of mitochondrial complex III (ubiquinol-cytochrome c oxidoreductase, cytochrome bc1 complex), integral to the mitochondrial respiratory chain. UQCRB binds ubiquinone and participates directly in the electron transport process, stabilizing mitochondrial complex III and supporting cellular oxygen sensing and hypoxia-induced angiogenesis via regulation of mitochondrial reactive oxygen species production. UQCRB is essential for mitochondrial energy generation and is implicated in mitochondrial diseases (notably complex III deficiency), various cancers, and cardiovascular disorders. UQCRB's expression and genetic variation serve as biomarkers in oncology and mitochondrial pathology, and it is a target for anti-angiogenic therapies, though therapeutic inhibition is limited by the risk of mitochondrial dysfunction and associated systemic toxicity[1][2][3][4].

Other names

Complex III subunit 7QP-CUbiquinol-cytochrome c reductase complex 14 kDa proteinQCR7UQBPUQCR6QPCMC3DN3Complex III subunit VIICytochrome b-c1 complex subunit 7

Inhibition of UQCRB disrupts electron transfer in complex III, suppressing mROS generation and downstream angiogenesis Modulation of UQCRB disrupts tumor cell metabolism and mitochondrial function