ubiquinol-cytochrome c reductase binding protein pseudogene (null)

The "ubiquinol-cytochrome c reductase binding protein pseudogene" is a human pseudogene related to the UQCRB gene, which encodes a subunit of mitochondrial complex III. Unlike functional genes, a pseudogene is a genomic DNA sequence similar to a gene but typically nonfunctional due to mutations or a lack of expression. This means it does not encode a protein and is not part of the mitochondrial respiratory chain[5][8]. No evidence supports its use as a receptor, therapeutic target, or marker for disease or therapy monitoring. The designation is problematic for drug target purposes because: - It is a pseudogene and not a protein or functional RNA product. - Pseudogenes, by definition, do not normally encode functional proteins or possess clear biological functions[5][8]. - The canonical drug target "ubiquinol-cytochrome c reductase binding protein" refers instead to the UQCRB protein, which is encoded by a different, protein-coding gene (ENSG00000156467), not this pseudogene[1][3]. - The gene symbol ENSG00000254373 is clearly marked as a pseudogene (e.g., as UQCRBP1)[7]. - Such pseudogenes are not considered therapeutic targets in pharmacology, biomedicine, or drug discovery[5][8]. If structured information about the canonical therapeutic target is required, the correct entity is "ubiquinol-cytochrome c reductase binding protein" (UQCRB), not this pseudogene. The current entry should not be treated as a valid molecular target for drug discovery, diagnostics, or therapeutic interventions.

Other names

UQCRBPUQCRBP1UQCRB pseudogene