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Target intelligence / Profile preview
Ubiquinol-cytochrome c reductase complex assembly factor 4 (UQCC4)
- Target
- UQCC4
- Molecular classification
- Assembly factor, Mitochondrial complex III assembly/stability factor
01
Overview
Ubiquinol-cytochrome c reductase complex assembly factor 4 (UQCC4) is a mitochondrial protein required for the assembly and stability of complex III (cytochrome b-c1 complex) in the electron transport chain. Dysfunction impacts mitochondrial oxidative phosphorylation and is associated with diseases such as mucolipidosis III gamma and alpha-2-plasmin inhibitor deficiency. UQCC4 is found in the mitochondria and, while its primary role is in respiratory chain biogenesis, it is reportedly upregulated in some cancers (notably lung cancer), suggesting a potential biomarker function. No approved therapeutics directly target this protein.
- Other names
- UQCC4C16orf91CCSMST1URLC5gs103up-regulated in lung cancer 5cattle cerebrum and skeletal muscle-specific protein 1 family memberProtein CCSMST1
02
Biological functions
Mitochondrial complex III assemblyElectron transport chain stabilityCellular respiration (Oxidative phosphorylation)
03
Disease associations
Mucolipidosis III gammaAlpha-2-plasmin inhibitor deficiencyCancer
04
Biomarkers
Up-regulated in lung cancer
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