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Target intelligence / Profile preview
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5)
- Target
- UQCC5
- Molecular classification
- Other (mitochondrial assembly factor)
01
Overview
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) is a protein located in the mitochondrial inner membrane that is essential for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III), as well as playing a role in the early steps of cytochrome c oxidase (complex IV) assembly. It mediates biogenesis of complex III, participates in regulating levels of electron transport chain proteins in response to cellular energy demands, and is required for proper mitochondrial respiratory function. UQCC5 enables mitochondrial ribosome binding activity and is active in mitochondrial inner membrane protein complex organization[1][5][6].
- Other names
- C3orf78SMIM4Small integral membrane protein 4UPF0640 protein C3orf78small integral membrane protein 4
02
Biological functions
Mitochondrial electron transport chain assemblyMitochondrial ribosome bindingRegulation of oxidative phosphorylationCytochrome c oxidase assembly
03
Disease associations
Other (no established direct disease role, but mitochondrial complexes are associated with mitochondrial disorders)
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