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Target intelligence / Profile preview
Ubiquinol-cytochrome c reductase complex core protein 1 (UQCRC1)
- Target
- UQCRC1
- Molecular classification
- Enzyme, Mitochondrial protein, Respiratory chain component
01
Overview
UQCRC1 is a core subunit of mitochondrial respiratory chain complex III (cytochrome bc1 complex), essential for oxidative phosphorylation and cellular energy production. It facilitates electron transfer from ubiquinol to cytochrome c, contributing to the proton gradient necessary for ATP synthesis. Defects in UQCRC1 can lead to mitochondrial disorders.
- Other names
- D3S3191QCR1UQCR1PKNPYCytochrome b-c1 complex subunit 1, mitochondrial
02
Mechanism of action
Inhibition of Complex III activity
03
Biological functions
Electron transportOxidative phosphorylationUbiquitin protein ligase binding
04
Disease associations
Mitochondrial disordersMetabolic disorders
05
Safety considerations
Impaired oxidative phosphorylationMitochondrial dysfunction
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