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Target intelligence / Profile preview
Ubiquitin–Proteasome System (UPS)
- Target
- UPS
- Molecular classification
- Enzyme complex
01
Overview
The ubiquitin–proteasome system (UPS) is the principal pathway for regulated protein degradation in eukaryotic cells. It is essential for maintaining cellular homeostasis by selectively degrading misfolded, damaged, or regulatory proteins and thus controls numerous cellular processes including cell cycle progression, signal transduction, and stress responses. The UPS involves ubiquitin tagging of target proteins by E1, E2, and E3 enzymes, followed by recognition and degradation by the 26S proteasome.
02
Mechanism of action
Inhibition of proteasome activity, leading to accumulation of polyubiquitinated proteins and cell death, particularly in cancer cells.
03
Biological functions
Selective intracellular protein degradationCell cycle controlApoptosisDNA repairSignal transductionEndocytosisMitochondrial maintenance/mitophagyT cell receptor signalingAngiogenesisDifferentiationCell proliferationRemoval of misfolded or damaged proteins
04
Disease associations
CancerNeurodegenerative disorders
05
Safety considerations
Toxicities associated with proteasome inhibitionPotential for off-target effects due to the broad role of the UPS in cellular processes
06
Interacting drugs
Proteasome inhibitors (e.g., Bortezomib)
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