Ubiquitin A-52 residue ribosomal protein fusion product 1 (UBA52)

Ubiquitin A-52 residue ribosomal protein fusion product 1 (UBA52) is a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 (eL40) at the C terminus[1][2][4]. This protein is post-translationally processed to release free ubiquitin, which targets cellular proteins for degradation by the 26S proteasome, and to supply the ribosomal protein L40, a component of the large (60S) ribosomal subunit essential for protein synthesis[2][3]. UBA52 is highly conserved across eukaryotes and functions as a housekeeping gene to maintain the basal ubiquitin pool for essential cellular processes, particularly in non-stress conditions[3]. UBA52 deficiency disrupts embryogenesis, cell cycle progression, and protein synthesis, leading to developmental arrest and cell death[1][3]. There is no evidence that UBA52 is directly targeted by drugs or used as a biomarker in clinical practice. However, its fundamental role in cellular homeostasis and development makes it indispensable for organismal viability.

Other names

Ubiquitin-ribosomal protein eL40 fusion proteinUbiquitin, Large ribosomal subunit protein eL40UBCEP2rpL40RPL40CEP52HUBCEP52MGC57125MGC126879MGC126881L40Ubiquitin-52 amino acid fusion proteinUbiquitin carboxyl extension protein 52Ubiquitin-60S ribosomal protein L4060S ribosomal protein L40