Ubiquitin-associated domain-containing protein 1 (UBAC1)

Ubiquitin-associated domain-containing protein 1 (UBAC1) is the non-catalytic subunit of the Kip1 ubiquitination-promoting complex (KPC), an E3 ubiquitin-protein ligase complex. The KPC complex mediates polyubiquitination and subsequent proteasomal degradation of proteins such as CDKN1B—a cyclin-dependent kinase inhibitor critical for cell cycle control during the G1 phase. UBAC1 functions as an adapter, facilitating the transfer of polyubiquitinated substrates to the 26S proteasome for degradation. It also regulates the NF-kappa-B signaling pathway by promoting maturation of NFKB1. UBAC1 is localized to the cytosol, Golgi apparatus, and plasma membrane. While it is associated with protein modification, maturation, and degradation processes, it is not a direct therapeutic drug target, and there are no FDA-approved drugs, clinical biomarkers, or reported safety concerns linked specifically to UBAC1[1][9][4][8].

Other names

UBAC1KPC2UBADC1GBDR1Kip1 ubiquitination-promoting complex protein 2Kip1 ubiquitination-promoting complex subunit 2UBA domain-containing protein 1E3 ubiquitin-protein ligase subunit KPC2Glialblastoma cell differentiation-related protein 1Putative glialblastoma cell differentiation-related proteinTesticular secretory protein Li 64