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Target intelligence / Profile preview
Ubiquitin carboxyl-terminal hydrolase 5 (USP5)
- Target
- USP5
- Molecular classification
- Enzyme, Deubiquitinase, Endopeptidase
01
Overview
Ubiquitin carboxyl-terminal hydrolase 5 (USP5), also known as isopeptidase T, is an enzyme in the ubiquitin-specific peptidase (USP) family that disassembles unanchored (not protein-conjugated) polyubiquitin chains and is critical for maintaining the free monoubiquitin pool in cells[1][2][3]. USP5 cleaves isopeptide bonds at the proximal end of polyubiquitin chains through a sequential exo mechanism, regulating protein turnover, DNA repair, localization, and cellular homeostasis[1][2][3]. Dysregulation of USP5 is implicated in cancer, neurological disease, and inflammatory processes, and USP5 is being explored as a therapeutic target with several small molecule inhibitors identified[1].
- Other names
- Ubiquitin specific peptidase 5Isopeptidase TISOTUbiquitin isopeptidase
02
Mechanism of action
Inhibition of deubiquitinating activity Disruption of polyubiquitin chain cleavage
03
Biological functions
Protein degradationUbiquitination and deubiquitinationProtein stabilizationProtein localizationDNA repairSignal transduction
04
Disease associations
CancerNeurological diseaseInflammation
05
Safety considerations
Potential for off-target effects due to broad cellular roleImpact on protein homeostasisUnknown long-term consequences of chronic inhibition
06
Interacting drugs
WP1130
7 more in the full profile.
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