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Ubiquitin carboxyl-terminal hydrolase 7 (USP7)
- Target
- USP7
- Molecular classification
- Enzyme, Deubiquitinase (DUB), Peptidase C19 family
01
Overview
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) is a deubiquitinating enzyme that removes ubiquitin from target proteins, regulating their stability and function. It plays a critical role in various cellular processes, including cell cycle control, DNA damage response, circadian rhythm, and neurogenesis. USP7 is a promising therapeutic target for oncology drug development due to its involvement in stabilizing oncogenic or tumor suppressor proteins. Dysregulation of USP7 is implicated in several diseases, including cancer, neurodevelopmental disorders, and drug addiction.
- Other names
- HAUSPHerpesvirus-associated ubiquitin-specific protease
02
Mechanism of action
USP7 inhibition aims to destabilize target proteins by preventing their deubiquitination, leading to their degradation or functional alteration.
03
Biological functions
Protein stabilizationProtein degradationCell cycle controlDNA damage responseCircadian rhythm regulationNeurogenesisEndosomal protein recyclingHistone modificationTranscription regulationEpigenetic regulation
04
Disease associations
CancerNeurodevelopmental disordersDrug addiction
05
Safety considerations
Potential for off-target effects due to the widespread role of USP7 in cellular processes.Development of resistance to USP7 inhibitors.
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