Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ubiquitin Carboxyl-Terminal Hydrolase L5 (UCHL5)
- Target
- UCHL5
- Molecular classification
- Enzyme, Peptidase C12 family, Ubiquitin C-terminal hydrolase, Deubiquitinating enzyme (DUB), Cysteine protease
01
Overview
Ubiquitin Carboxyl-Terminal Hydrolase L5 (UCHL5) is a cysteine protease and deubiquitinating enzyme (DUB) that cleaves 'Lys48'-linked polyubiquitin chains from substrate proteins. It is associated with the 19S regulatory subunit of the 26S proteasome and plays a key role in protein degradation. UCHL5 participates in various cellular processes, including protein deubiquitination, regulation of primary metabolic processes, and positive regulation of the smoothened signaling pathway. Overexpression has been linked to various cancers, particularly endometrial cancer, through Wnt/β-catenin pathway activation. Dysregulation may also play roles in neurodegeneration.
- Other names
- UCH37ubiquitin carboxyl-terminal hydrolase isozyme L5
02
Mechanism of action
Catalyzes removal of ubiquitin from polyubiquitinated substrates.
03
Biological functions
Protein deubiquitinationRegulation of primary metabolic processesPositive regulation of smoothened signaling pathwayProteasomal protein degradationRegulation of β-catenin destruction complex function
04
Disease associations
Cancer progression/metastasisPossible neurodegeneration
05
Safety considerations
Embryonic lethality upon UCHL5 disabling in mice.
Beyond the preview
Go deeper on Ubiquitin Carboxyl-Terminal Hydrolase L5 (UCHL5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ubiquitin Carboxyl-Terminal Hydrolase L5 (UCHL5).