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Target intelligence / Profile preview
Ubiquitin carboxyl-terminal hydrolase OTUB1 (OTUB1)
- Target
- OTUB1
- Molecular classification
- Enzyme, Cysteine protease, Deubiquitinase
01
Overview
OTUB1 is a deubiquitinating enzyme that removes ubiquitin from target proteins, primarily K48-linked polyubiquitin chains. It regulates various cellular processes including DNA repair, energy metabolism, and hormone receptor signaling. It is involved in cancer progression through its effects on ERα and mTOR pathway components.
- Other names
- Otubain-1OTB1OTU1HSPC263OTU deubiquitinaseubiquitin aldehyde binding 1
02
Mechanism of action
Deubiquitinates K48-linked polyubiquitin chains; inhibits E2 enzyme activity
03
Biological functions
DeubiquitinationProtein metabolismDNA repair regulationEnergy metabolism controlHormone receptor modulation
04
Disease associations
Machado-Joseph DiseaseAutosomal Dominant Cerebellar AtaxiaCancer
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