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Target intelligence / Profile preview
Ubiquitin-conjugating enzyme E2 C (UBE2C)
- Target
- UBE2C
- Molecular classification
- Enzyme, Ubiquitin-conjugating enzyme
01
Overview
Ubiquitin-conjugating enzyme E2 C (UBE2C) is an E2 ubiquitin-conjugating enzyme that plays a crucial role in the ubiquitination pathway. This enzyme accepts ubiquitin from an E1 activating enzyme and catalyzes its covalent attachment to substrate proteins, typically with assistance from an E3 ligase. This process is vital for targeting abnormal or short-lived proteins for degradation and regulating cell cycle progression, particularly through the destruction of mitotic cyclins. UBE2C's overexpression or dysregulation has been implicated in various cancers, making it a potential biomarker and therapeutic target.
02
Mechanism of action
Not applicable, UBE2C is the target, not the drug.
03
Biological functions
UbiquitinationProtein degradationCell cycle regulationMitosis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to ubiquitination's broad role in cellular processes.
06
Biomarkers
UBE2C expression levels in cancer tissues
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