Target intelligence / Profile preview

Ubiquitin-conjugating enzyme E2 K (UBE2K)

Target: UBE2K
Molecular classification: Enzyme, Ubiquitin-conjugating enzyme (E2)

Overview

Ubiquitin-conjugating enzyme E2 K (UBE2K) is an E2 ubiquitin ligase involved in the ubiquitination pathway, specifically the synthesis of Lys48-linked polyubiquitin chains, targeting proteins for proteasomal degradation. It participates in ERAD, DNA damage repair, apoptosis regulation, and other cellular processes. UBE2K interacts with proteins like Huntingtin (HTT) and RNF2. Aberrant UBE2K activity has been implicated in cancer progression and neurodegenerative diseases.

Other names: E2-25KHIP2HYPGLIGUBC1

Mechanism of action

Inhibiting or modulating the ubiquitination process facilitated by UBE2K.

Biological functions

UbiquitinationProtein degradationER-associated degradation (ERAD)DNA damage repairRegulation of apoptosis

Disease associations

CancerNeurodegenerative diseaseViral infection

Safety considerations

Off-target effects due to involvement in multiple cellular processes.Potential for dysregulation of protein homeostasis if ubiquitination is disrupted.

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