Ubiquitin-conjugating enzyme E2 N-like (UBE2NL)

Ubiquitin-conjugating enzyme E2 N-like (UBE2NL) is an intronless gene annotated as a member of the E2 ubiquitin-conjugating enzyme family, but it is primarily annotated as a polymorphic pseudogene in humans; some individuals have an allele encoding a full-length protein, while others have a non-functional allele with a premature stop codon[1][3][2]. The protein is 91% identical to UBE2N, a core E2 enzyme, but the function of UBE2NL remains uncharacterized and there is no established role in human disease or therapeutic targeting[3][2][5][1]. Most recent literature classifies UBE2NL as a pseudogene with uncertain protein-coding capability and unknown biological function[1][2][3]; there are no reported interacting drugs, disease links, or validated clinical biomarker data for this gene.

Other names

Putative ubiquitin-conjugating enzyme E2 N-likeEpididymis tissue protein Li 174Li174Ubiquitin conjugating enzyme E2N-likeUBE2NL