Ubiquitin-conjugating enzyme E2 pseudogene

Ubiquitin-conjugating enzyme E2 pseudogene (ENSG00000225460, also referred to as LOC124902324) is a **pseudogene**, which is a nonfunctional segment of DNA that resembles functional ubiquitin-conjugating enzyme E2 genes. Pseudogenes arise by gene duplication or retrotransposition events and accumulate mutations that disable their ability to code for a functional protein[2][8][6]. Ubiquitin-conjugating enzymes (E2 enzymes) are responsible for the ubiquitination of proteins, playing a role in targeting proteins for degradation by the proteasome[1]. However, this particular locus does not produce an active enzyme or participate in the ubiquitination pathway[2][8][6]. Pseudogenes are generally not considered therapeutic targets, though some pseudogenes elsewhere in the genome have been found to carry regulatory roles via RNA-level effects, these are the exception rather than the rule and require specific evidence not provided for this locus[4][6].

Other names

LOC124902324ENSG00000225460ubiquitin-conjugating enzyme E2 pseudogene