Ubiquitin-conjugating enzyme E2 Q1 (UBE2Q1)

Ubiquitin-conjugating enzyme E2 Q1 (UBE2Q1) is a member of the E2 ubiquitin-conjugating enzyme family, catalyzing the covalent attachment of ubiquitin to substrate proteins[5][6]. It is involved in both canonical and noncanonical ubiquitylation, uniquely capable of attaching ubiquitin to not only lysine but also serine, threonine, cysteine, and even complex sugars or glucose residues[1]. UBE2Q1 contains an extended N-terminal domain and an RWD domain, and can function independently of E3 ligases for certain noncanonical substrates. It shows substrate specificity and is implicated in hormonal regulation and potentially tumor biology, although detailed clinical targeting information and drugs are currently lacking[6][1].

Other names

NICE5UBE2QPRO3094NICE-5E2 ubiquitin-conjugating enzyme Q1Protein NICE-5Ubiquitin carrier protein Q1Ubiquitin-protein ligase Q1GTAPgalactosyl transferase-associated proteinubiquitin conjugating enzyme E2Q family member 1ubiquitin-conjugating enzyme E2Q (putative) 1

Drugs (if developed) would likely act as inhibitors or modulators of protein ubiquitin-conjugation activity.