Ubiquitin conjugating enzyme E2 T (UBE2T)

Ubiquitin conjugating enzyme E2 T (UBE2T) is an E2 class enzyme central to the post-translational modification of proteins via ubiquitination, serving a pivotal role in the Fanconi anemia DNA repair pathway through its association with E3 ligase FANCL and its ability to monoubiquitinate critical substrates such as FANCD2 and FANCI. Deficiency or mutation of UBE2T leads to Fanconi anemia (subtype FA-T), and its dysregulation is linked to cancer development, metastatic behavior, cell cycle control, apoptosis, and resistance to therapy. Drugs and inhibitors targeting UBE2T are under preclinical study, highlighting its value as a molecular target in oncology and hematologic disorders[1][2][4][5][6].

Other names

UBE2TE2 ubiquitin-conjugating enzyme TFANCTPIG50HSPC150

Small molecule inhibition: blocks UBE2T-mediated degradation of RACK1, suppresses Wnt/β-catenin signaling, inhibits proliferation and invasion siRNA and genetic knockdown: G2/M cell cycle arrest, increased apoptosis