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Ubiquitin-conjugating enzyme E2D N-terminal like

Molecular classification: Enzyme

Overview

Ubiquitin-conjugating enzyme E2D N-terminal like (ENSG00000229547) refers to a gene locus annotated in genome databases as homologous to the N-terminal region of E2 ubiquitin-conjugating enzyme family members. In contrast to canonical E2 enzymes, which catalyze the transfer of ubiquitin from E1 activating enzymes to specific protein substrates and play key roles in cellular protein homeostasis[1], there is currently no functional evidence that ENSG00000229547 encodes an active enzyme. The designation "N-terminal like" typically signifies a pseudogene, fragment, or predicted protein without characterized activity. As such, it is not considered a bona fide therapeutic target and there may be issues with annotation, misspelling, or lack of biological relevance.

Other names: LOC100507516

Biological functions

Unknown. Typical functions of canonical E2 ubiquitin-conjugating enzymes include mediating the attachment of ubiquitin to substrate proteins during ubiquitination[1]. This specific predicted gene has no known functional validation.If active, similar homologs participate in protein degradation, DNA repair, cell cycle regulation, and signal transduction[1].

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