Ubiquitin-conjugating enzyme E2G1 pseudogene

Ubiquitin-conjugating enzyme E2G1 pseudogene (ENSG00000227962), as indicated by its classification, is a pseudogene related to the functional ubiquitin-conjugating enzyme E2 (UBE2G1 or UBE2G10); however, it does not encode a functional protein. Pseudogenes of this class are often non-protein-coding elements that may act as long non-coding RNAs. Some pseudogenes, such as UBE2MP1 (a homolog derived from UBE2M, not UBE2G1), have been shown to regulate cancer-related processes via competing endogenous RNA (ceRNA) networks and modulation of miRNA pathways in hepatocellular carcinoma. There is no direct evidence that UBE2G10 pseudogene (ENSG00000227962) is a therapeutic target, nor that it encodes a functional protein, nor that drugs interact directly with it. Key points: - The entry is for a pseudogene and not an active enzyme, receptor, or recognized direct drug target. - Pseudogenes may have regulatory RNA functions, but therapeutic targeting is not established for this entry. - The gene symbol UBE2G10 usually refers to Ubiquitin-conjugating enzyme E2 G10, but the designation "pseudogene" here (and ENSG00000227962) means this gene is not functional. - No canonical abbreviation is used for pseudogenes in the way used for protein targets. - There are no approved drugs, mechanisms of action, or validated biomarker or safety data attached to this pseudogene. - There is likely a mistake or mix-up here if the intention was to refer to the canonical UBE2G1 enzyme; if so, UBE2G1/UBE2G10 should refer to the active enzyme, not the pseudogene. Summary of Issues: - This is not a valid therapeutic target. - The entity is a pseudogene and thus not a direct molecular target for drugs. - No evidence for clinical, pharmacological, or target-based activity. - Recording as a target would be incorrect.

Other names

UBE2G10 pseudogeneENSG00000227962