Ubiquitin-conjugating enzyme E2I pseudogene

The ubiquitin-conjugating enzyme E2I pseudogene (ENSG00000225943) is a genomic region in humans that resembles the UBE2I gene but is nonfunctional and does not code for an active protein. Pseudogenes are nonfunctional segments of DNA similar to known genes, typically rendered inactive by mutations such as frameshifts or early stop codons[4]. While the protein-coding UBE2I gene is central to cellular protein degradation processes via the ubiquitination pathway[1][3], the corresponding pseudogene plays no established biological role and is not used as a therapeutic target. In rare cases, pseudogenes may generate regulatory RNAs, but there is no evidence that this specific pseudogene is functionally significant in health or disease[6]. Key Notes: - Pseudogenes are defined by the lack of protein-coding capacity despite sequence similarity to functional genes[2][4]. - They sometimes complicate genetic studies by sequence similarity but are not pursued as therapeutic drug targets[4]. - The functional UBE2I gene (not this pseudogene) encodes a SUMO-conjugating enzyme involved in many cellular processes, but all known aliases, disease roles, and functions belong to the protein-coding gene, not its pseudogene[1][3].

Other names

UBE2I pseudogeneUBC9 pseudogene