Ubiquitin-like-conjugating enzyme ATG10 (ATG10)

Ubiquitin-like-conjugating enzyme ATG10 (ATG10) is a cytoplasmic protein acting as an E2-like enzyme. It plays a central role in the autophagy pathway by mediating the conjugation of ATG12 to ATG5, an essential step in autophagosome formation and maturation[2][3][4][7]. ATG10 has two isoforms in humans: the canonical long isoform and a shorter isoform (ATG10S), which may exert distinct effects on viral replication and autophagy flux[1]. ATG10 is implicated in neurodegenerative disorders, viral infections (notably hepatitis C), and cancer through its role in cellular degradation processes and cell survival[1][2]. It functions as part of the ubiquitin-like protein conjugation system, distinguishing it from traditional ubiquitin E2 enzymes via unique structural features[3]. ATG10 may serve as a therapeutic target for modulating autophagy in diseases where this process is dysregulated[1][2].

Other names

Autophagy related 10Autophagy-related protein 10ATG10APG10APG10LAPG10-likeDKFZP586I0418FLJ13954PP12616Ubiquitin-like-conjugating enzyme ATG10ATG10 autophagy related 10 homolog

Modulation of autophagy flux (restoration or inhibition); Inhibition or enhancement of ATG12-ATG5 conjugation; Promotion or suppression of autophagosome formation[1]