Ubiquitin-like with PHD and RING finger domains 2 (UHRF2)

Ubiquitin-like with PHD and RING finger domains 2 (UHRF2) is a nuclear protein and E3 ubiquitin ligase involved in cell-cycle regulation, DNA methylation, histone modification, and DNA repair. It contains multiple functional domains including a PHD finger, SRA (SET and RING-associated) domain, and a RING finger domain. UHRF2 can ubiquitinate specific substrates (such as PCNP, cyclins, and p21) and plays roles in the maintenance of genomic stability, cell-cycle progression, and may contribute to tumorigenesis. It also participates in intranuclear degradation of polyglutamine aggregates and is implicated in cellular response to DNA damage.

Other names

UHRF2RNF107NIRFTDRD23URF2Ubiquitin-Like With PHD And RING Finger Domains 2, E3 Ubiquitin Protein LigaseRING-Type E3 Ubiquitin Transferase UHRF2E3 Ubiquitin-Protein Ligase UHRF2Np95-Like RING Finger ProteinRING Finger Protein 107Nuclear Protein 97MGC33463Nuclear Zinc Finger Protein NP97EC 2.3.2.27EC 6.3.2

Modulation of cell cycle checkpoint regulation; Induction of cell cycle arrest (through ubiquitination of cyclins); Alteration of DNA methylation and histone modification; Promotion or inhibition of protein degradation via the proteasome