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Target intelligence / Profile preview
Ubiquitin Proteasome System (UPS)
- Target
- UPS
- Molecular classification
- Enzyme complex, Protein degradation pathway
01
Overview
The ubiquitin proteasome system (UPS) is the principal pathway for targeted protein degradation in eukaryotic cells. It is essential for maintaining cellular protein homeostasis by selectively degrading misfolded, damaged, or regulatory proteins that control various cellular processes. The UPS involves ubiquitin, E1, E2, and E3 enzymes, polyubiquitin chains, and the 26S proteasome complex, which consists of the 20S core and two 19S regulators. Dysregulation of the UPS is implicated in various diseases, making it a therapeutic target.
02
Mechanism of action
Pharmacological inhibition or modulation of UPS components
03
Biological functions
Selective intracellular protein degradationCell cycle regulationStress responseRemoval of abnormal/damaged proteinsRegulation of apoptosisRegulation of DNA repairImmune response via antigen processing
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Off-target effectsDevelopment of resistancePotential for immune-related adverse events
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