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Target intelligence / Profile preview
Ubiquitin protein ligase E3A antisense transcript (UBE3A-ATS)
- Target
- UBE3A-ATS
- Molecular classification
- Long non-coding RNA
01
Overview
The Ubiquitin protein ligase E3A antisense transcript (UBE3A-ATS) is a long non-coding RNA (lncRNA) transcribed from the antisense DNA strand at the UBE3A gene locus. It functions primarily to silence the paternal copy of UBE3A in neurons through transcriptional interference. UBE3A-ATS plays a key regulatory role in genomic imprinting and its disruption is a potential therapeutic strategy for Angelman Syndrome.
- Other names
- SNHG14LNCATNCRNA00214UBE3A-ASUBE3A-AS1UBE3AATSsmall nucleolar RNA host gene 14
02
Mechanism of action
Disruption or inhibition of UBE3A-ATS to unsilence the paternal UBE3A allele.
03
Biological functions
Transcriptional interferenceRegulation of gene expressionGenomic imprintingSilencing of paternal UBE3A allele
04
Disease associations
Angelman SyndromeNeurodevelopmental disorders
05
Safety considerations
Off-target effects of antisense oligonucleotides or genome editing tools.Potential for unintended consequences of altering genomic imprinting.
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