Ubiquitin-protein ligase E3D (UBE3D)

Ubiquitin-protein ligase E3D (UBE3D) is a member of the HECT (Homologous to E6AP Carboxyl Terminus) domain-containing E3 ubiquitin ligases, enzymes that mediate the transfer of ubiquitin molecules to specific substrate proteins, thereby regulating their degradation, activity, or cellular location[1][3]. UBE3D functions at least in part through interactions with ubiquitin-conjugating enzymes (E2s), such as UBE2C, and substrates like cyclin B. It plays a crucial role in processes such as the DNA damage response, especially homologous recombination-mediated repair in heterochromatin regions, by facilitating chromatin relaxation and coordinating the recruitment of DNA repair factors (e.g., PCNA and KAP1)[1]. Mutations of UBE3D, including the V379M variant, have been associated with diseases such as age-related macular degeneration, possibly via impaired recruitment of DNA repair cofactors under oxidative stress[1]. UBE3D is considered a potential drug target in oncology and age-related eye diseases, but currently there are no drugs directly targeting this ligase for therapeutic purposes[1][3].

Other names

UBE3DC6orf157H10BHUBE2CBPDKFZp434A1520YJR141WHECT-type E3 ubiquitin transferase E3DUbcH10-binding protein with a HECT-like domainUbiquitin-conjugating enzyme E2C-binding proteinUBCH10 binding protein with a HECT-like domain