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Target intelligence / Profile preview
Ubiquitin specific peptidase 1 (USP1)
- Target
- USP1
- Molecular classification
- Enzyme, UBP family, Peptidase C19, Deubiquitinating enzyme (DUB)
01
Overview
USP1 is a deubiquitinating enzyme (DUB) belonging to the UBP family. It plays a crucial role in DNA damage response and repair by regulating the ubiquitylation status of key proteins like FANCD2, FANCI, and PCNA. USP1 is involved in the Fanconi anemia pathway and autophagy regulation. It is a therapeutic target in cancer, particularly in BRCA-mutant tumors, where its inhibition shows synthetic lethality with PARP inhibitors.
02
Mechanism of action
Inhibition of USP1 activity leads to accumulation of ubiquitinated substrates and disruption of DNA repair pathways.
03
Biological functions
DNA damage response/repairProtein catabolismAutophagy regulationRegulation of DNA repairDeubiquitination
04
Disease associations
Cancer progression/resistanceFanconi anemia
05
Safety considerations
Potential for off-target effects due to the broad role of deubiquitinating enzymes.Development of resistance mechanisms.
06
Interacting drugs
Olaparib
1 more in the full profile.
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