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Target intelligence / Profile preview
Ubiquitin specific peptidase 17-like family member 10 (USP17L10)
- Target
- USP17L10
- Molecular classification
- Enzyme, Deubiquitinating enzyme, Cysteine protease
01
Overview
Ubiquitin specific peptidase 17-like family member 10 (USP17L10) is a protein-coding deubiquitinating enzyme on chromosome 4 involved in the removal of ubiquitin tags from substrate proteins, thereby modulating multiple cellular processes. It regulates protein stability, cell growth and cycle progression, apoptosis, cell motility, and immune responses. USP17L10 is highly expressed in certain cancers and is essential for chemokine-induced cell migration, functioning downstream of chemokine receptors to facilitate cytoskeletal rearrangement via small GTPase localization. It is implicated in diverse pathological processes, from immunodeficiency syndromes to metastatic cancer, suggesting its importance as a therapeutic target in oncology and immunology[1][2][3][5].
- Other names
- Ubiquitin carboxyl-terminal hydrolase 17-like protein 10USP17L10Ubiquitin specific peptidase 17-like family member 10
02
Mechanism of action
Inhibition of deubiquitinase activity, leading to disrupted protein stabilization and dysregulation of cell proliferation, migration, and apoptosis
03
Biological functions
Ubiquitin removal and protein stability regulationCell proliferationCell cycle progression (especially G1/S phase)ApoptosisCell migration and chemotaxisImmune response (including response to viral infection)
04
Disease associations
Cancer (especially in tumor-derived cell lines; regulates proliferation and migration)Alzheimer diseaseImmunodeficiencies (e.g., immunodeficiency 19, 73c, 99, 105, 18, 76, severe combined immunodeficiency)Combined immunodeficiency with skin granulomasObesity due to leptin or leptin receptor deficiencySpermatogenic failureCommon variable immunodeficiencyInflammation (regulator of migration, especially relevant in metastatic disease and tissue inflammation)
05
Safety considerations
As with other cell cycle and migration regulators, inhibition may impair tissue homeostasis and immune functionPotential risk for immunosuppression or impaired wound healing if broadly targeted
06
Biomarkers
Overexpression in tumor cells (serves as a biomarker for tumor cell proliferation and migration)Upregulation in response to chemokines (possible biomarker for chemotactic activity in inflammatory and cancerous tissues)
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