Ubiquitin specific peptidase 17-like family member 11 (USP17L11)

Ubiquitin specific peptidase 17-like family member 11 (USP17L11) is a protein-coding gene predicted to encode a cysteine-type deubiquitinase enzyme. Deubiquitinases like USP17L11 remove ubiquitin groups from target proteins, thereby regulating protein stability and turnover. USP17L11 is predicted to be active in the cytosol and nucleus and is involved in the regulation of apoptotic processes and protein stability. Disease association information is limited, but deubiquitinases including USP17L11 are generally implicated in critical cellular processes such as apoptosis and may play roles in cancer progression or suppression. Its molecular function overlaps with related enzymes such as USP11, with activities suggested in cell death modulation rather than direct signaling or transport[3]. There is no specific drug known to target USP17L11 as of September 2025, and further clinical relevance remains to be established. The gene is cataloged under GeneCards, Ensembl, NCBI Gene, and UniProt with multiple sequence and protein IDs[3][2].

Other names

Ubiquitin carboxyl-terminal hydrolase 17-like protein 11USP17L11U17LB proteinGC04P009218GC04P009219GC04P009235GC04P010110GC04P029954

Drugs targeting deubiquitinases generally act as enzyme inhibitors, blocking the removal of ubiquitin and thus modulating protein turnover and function. Specific mechanisms for USP17L11 are unknown; other USP family inhibitors employ cysteine protease inhibition.