Ubiquitin specific peptidase 17 like family member 7 (USP17L7)

Ubiquitin specific peptidase 17 like family member 7 (USP17L7) is a protein-coding gene that belongs to the peptidase C19 family, specifically the USP17 subfamily of deubiquitinating enzymes[5]. It is predicted to have cysteine-type deubiquitinase activity, with a potential role in the regulation of protein stability and apoptotic processes. USP17L7 is predicted to localize to the endoplasmic reticulum, cytosol, and nucleus[5]. While the USP17 gene family (including canonical USP17, also known as DUB-3) has been shown to regulate cell proliferation, cell cycle, and apoptosis—and has been studied as a putative therapeutic target in cancer and inflammation through its roles in cell migration, GTPase localization, and cytoskeletal dynamics—there is currently no strong evidence that USP17L7, specifically, is an active deubiquitinase or directly validated as a drug target[1][2][3][5]. The abbreviation "Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7" further suggests this member may lack enzymatic activity[5]. Notes on correctness: There is a significant likelihood that USP17L7 is a pseudogene or an inactive paralog within the USP17 deubiquitinase family, as indicated by its "inactive" naming and gene summaries[5]. Most research and drug targeting is focused on closely related, catalytically active family members (e.g., USP17, USP17L2), not on USP17L7, and there are no known drugs, clinical roles, or established biomarkers relating to USP17L7 specifically[1][5]. Summary: USP17L7 is an enzyme-like protein of the USP17 subfamily that is predicted, but not confirmed, to have deubiquitinating enzyme activity. It is not currently considered a validated drug target, nor are there therapies specifically directed at it. Its main value currently is as a gene/protein annotation closely related to other USP17 family deubiquitinases, which are actively studied for their roles in cell proliferation, apoptosis, and disease[1][2][5].

Other names

Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7Ubiquitin specific peptidase 17-like 7USP17L7U17L7