Ubiquitin specific peptidase 17-like family member 8 (USP17L8)

Ubiquitin specific peptidase 17-like family member 8 (USP17L8) is a predicted member of the deubiquitinating enzyme family, which are cysteine proteases involved in removing ubiquitin moieties from substrate proteins[4]. It is classified as "predicted to enable cysteine-type deubiquitinase activity," but its specific enzymatic activity has not been experimentally validated, and the protein may be catalytically inactive[4]. The gene is located on chromosome 8 and is part of a family of USP17-related genes that are primarily implicated in regulating cellular processes like protein stability and the cell cycle, based on the established functions of other USP17 family members[1][2][4]. However, no direct biological function, disease association, nor any drug interaction has been described for USP17L8 specifically in the biomedical literature as of this time. This entry is considered incorrect as a therapeutic target because the "USP17L8" protein is not experimentally validated as an active enzyme or disease-related target; most functional and mechanistic data available apply to other paralogs in the USP17 family (such as USP17, DUB3/USP17, or related isoforms), but not to USP17L8 directly[2][4]. There is significant risk of conflating the broad, established literature for *USP17* with the much less characterized *USP17L8*. Key notes: - USP17L8 is *predicted* to be a deubiquitinating enzyme but may have no demonstrated enzymatic or disease-modifying role[4]. - It is not currently recognized as a therapeutic target; the name and sequence suggest family association, but actual activity and function are uncertain[2][4]. - Most literature on the USP17 family refers to other paralogs (like USP17/USP17A/USP17B/etc.), not specifically USP17L8[2][4]. - There is no evidence for direct drug targeting, biomarker utility, or known disease linkage for USP17L8.

Other names

Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8USP17L10ubiquitin specific peptidase 17-like 8