Ubiquitin specific peptidase 9, Y-linked pseudogene 18 (USP9YP18)

USP9YP18 (ubiquitin specific peptidase 9, Y-linked pseudogene 18) is a pseudogene located on the Y chromosome in humans. Unlike the functional USP9Y gene, which codes for an active deubiquitinating enzyme involved in sperm production and male fertility, USP9YP18 does not produce a functional protein and is not considered a therapeutic target, nor is there evidence for its use as a biomarker or its involvement in disease mechanisms. ### Context and Supporting Information - **Pseudogene Status:** USP9YP18 is explicitly identified as a pseudogene and is listed alongside other Y-linked pseudogenes in genomics databases and bioinformatics references. - **Gene Location:** It resides on the Y chromosome (chrY:23659466-23667822, hg38 genome build). - **Relationship to USP9Y:** While the functional gene USP9Y has a validated role in male fertility and encodes a deubiquitinating enzyme, pseudogenes such as USP9YP18 are non-functional copies or fragments of genes and do not encode an active enzyme or protein. - **No Drug or Clinical Associations:** No data support drug interactions, clinical roles, or therapeutic interest for this pseudogene. ### Notes on Appropriateness and Potential Errors - The target USP9YP18 is not a therapeutic target and should not be considered equivalent to the functional USP9Y enzyme. - It is not a protein-coding gene, and there may have been confusion with the clinically relevant gene USP9Y, which is a target of biological interest. In sum, **USP9YP18** is a non-protein-coding Y-linked pseudogene with no known biological function, disease relationship, or relevance as a therapeutic target.

Other names

USP9YP18USP9Y pseudogene 18