Ubiquitin specific peptidase 9, Y-linked pseudogene 27 (USP9YP27)

USP9YP27 (Ubiquitin specific peptidase 9, Y-linked pseudogene 27) is a Y-chromosome pseudogene. Pseudogenes are genomic DNA sequences similar to known genes but are non-functional due to mutations, loss of regulatory elements, or lack of complete open reading frames. Unlike the canonical USP9Y gene, which codes for a deubiquitinase important for male germ cell development and is linked to male infertility, the USP9YP27 pseudogene does not encode a protein, is not involved in any known biological processes or disease mechanisms, has no drug interactions, and is not used as a biomarker[5][2][6][7]. It is identified as a non-protein-coding element in human genome annotation. The presence of USP9Y pseudogenes (such as USP9YP27) on the Y chromosome likely reflects gene duplication events but has no known direct functional consequence[4][5]. Queries about "USP9YP27" sometimes arise from confusion with USP9Y, which is a valid therapeutic target and protein-coding gene associated with male infertility[6][3][1][7]. USP9YP27 is specifically a pseudogene; conflation with USP9Y will lead to incorrect attribution of biological and therapeutic properties.

Other names

USP9YP27USP9Y pseudogene 27ubiquitin specific peptidase 9, Y-linked pseudogene 27

None described. No mechanism established due to lack of functional protein.