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Target intelligence / Profile preview
Ubiquitin-specific protease 1
- Molecular classification
- Deubiquitinating enzyme, Cysteine protease
01
Overview
Ubiquitin-specific protease 1 (USP1) is a deubiquitinating enzyme that plays a crucial role in regulating protein stability and function by removing ubiquitin moieties from target proteins. USP1 is particularly important for DNA damage repair and cell cycle regulation. Overexpression or dysregulation of USP1 has been linked to various cancers, while its inhibition has shown therapeutic potential in diseases like diabetes by inhibiting DNA damage-induced pancreatic β-cell apoptosis.
- Other names
- USP1
02
Mechanism of action
Deubiquitination of target proteins, reversing ubiquitination and affecting protein stability and function. Inhibitors of USP1 prevent this deubiquitination.
03
Biological functions
Removes ubiquitin from substratesRegulates protein stability and functionDNA damage repairCell cycle regulationProtein Stabilization
04
Disease associations
CancerGastric cancerHepatocellular carcinomaBladder cancerDiabetes
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