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Target intelligence / Profile preview
Ubiquitin-specific protease 14 (USP14)
- Target
- USP14
- Molecular classification
- Enzyme, Deubiquitinating enzyme (DUB), Cysteine peptidase
01
Overview
Ubiquitin-specific Protease 14 (USP14) is a highly regulated deubiquitinating enzyme crucial for maintaining cellular protein homeostasis. Its dual roles at the interface between ubiquitination-mediated signaling/degradation make it both a fundamental biological regulator and an attractive target for therapeutic intervention across oncology, neurology, immunology, and infectious disease fields.
02
Mechanism of action
Inhibition of USP14 activity
03
Biological functions
Protein deubiquitinationRegulation of ubiquitin-proteasome system (UPS)Cell cycle regulationAutophagyImmune responseProtein homeostasis
04
Disease associations
CancerNeurodegenerative diseaseViral infectionsInflammation-related conditions
05
Safety considerations
Potential for off-target effects due to broad role in protein homeostasisUnknown long-term consequences of USP14 inhibition
06
Interacting drugs
IU1
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