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Ubiquitin-specific protease 30 (None)
- Target
- None
- Molecular classification
- Enzyme, Deubiquitinating enzyme (DUB), USP Subfamily
01
Overview
Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) primarily localized to the mitochondrial outer membrane and peroxisomes. It regulates mitochondrial quality control, cellular metabolism, and various signaling pathways by removing ubiquitin from specific protein substrates. USP30 negatively regulates PINK1/Parkin-mediated mitophagy and is involved in apoptosis, lipid metabolism, tumorigenesis, and NLRP3 inflammasome activation. It is a therapeutic target for diseases such as Parkinson's disease and cancer, with several small-molecule inhibitors in development.
02
Mechanism of action
Inhibition of deubiquitination activity, leading to increased ubiquitination of target proteins and subsequent modulation of downstream pathways such as mitophagy and inflammasome activation.
03
Biological functions
Mitophagy regulationPexophagy regulationApoptosis modulationRegulation of lipid metabolismRegulation of tumorigenesisRegulation of NLRP3 inflammasome activation
04
Disease associations
Parkinson's diseaseNeurodegenerative diseasesHepatocellular carcinomaPulmonary disordersPeroxisome biogenesis disordersAutism Spectrum Disorder
05
Interacting drugs
MTX652
2 more in the full profile.
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