Ubiquitously expressed prefoldin-like chaperone (UXT)

Ubiquitously expressed prefoldin-like chaperone (UXT) is a small, highly conserved protein involved in the regulation of androgen receptor-dependent transcription, apoptosis, autophagy, and immune signaling[3][4][6]. UXT acts as a nuclear and cytoplasmic chaperone, regulating transcriptional complexes—including those for NF-κB and androgen receptor—and interacting with key factors in programmed cell death, cellular proteostasis (including autophagy via p62/SQSTM1), and the maintenance of centrosome structure[1][2][4][6]. UXT is widely expressed, with enhanced or altered expression implicated in tumorigenesis and neurodegenerative pathologies[1][3][4]. Multiple isoforms exist, with distinct cellular locations and functions in death receptor signaling and gene regulation[3][4]. There are currently no clinically validated drugs that directly target UXT, and its essential cellular roles indicate safety challenges if it were considered for therapeutic targeting[1][3][4].

Other names

Protein UXTHSPC024ART-27STAP1SKP2-associated alpha PFD 1Androgen receptor trapped clone 27 proteinUbiquitously expressed transcript proteinandrogen receptor trapped clone 27