UBTF like 2 (pseudogene) (UBTFL2)

UBTF like 2 (UBTFL2) is a human pseudogene located on chromosome 11 (chr11:89752785-89753975, according to hg38 reference genome) that derives its name from similarity to the upstream binding transcription factor (UBTF), a key activator of ribosomal RNA gene transcription, but UBTFL2 itself is annotated as a pseudogene, implying that it is not transcribed or translated as a functional protein[4][5]. There is no evidence to suggest UBTFL2 is involved in biological processes or human disease. It is not considered a therapeutic target, and there are no known drug interactions, disease roles, or biomarker applications associated with UBTFL2[4][5].\n\nKey clarification:\nUBTFL2 should not be confused with UBTF (Upstream Binding Transcription Factor, also called UBF), a functional DNA-binding protein with established roles in RNA polymerase I transcription and disease, particularly leukemia and neurodegenerative conditions[2]. UBTFL2 is distinct and refers only to the pseudogene[4][5].

Other names

upstream binding transcription factor, RNA polymerase I-like 2 (pseudogene)