UBX domain-containing protein 2B (UBXN2B)

UBX domain-containing protein 2B (UBXN2B) is an adapter protein belonging to the ubiquitin regulatory X (UBX) domain family. It is primarily involved in the **maintenance and biogenesis of the Golgi apparatus and endoplasmic reticulum during the cell cycle**, playing key roles in membrane fusion and reassembly at the end of mitosis. UBXN2B functions as a **cofactor for p97/VCP (an ATPase involved in diverse cellular functions including protein degradation)**, assisting in the regulation of protein homeostasis. It also participates in **regulating mitotic spindle orientation and centrosomal protein localization**, especially influencing the removal of Aurora kinase A from centrosomes during prophase. Diseases associated with alterations or mutations in UBXN2B include **inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia and Brown-Séquard syndrome**. Although the UBX domain protein family is implicated in several cancers, UBXN2B itself does not have well-characterized roles as a direct disease driver or therapeutic target, nor are there any drugs or clinical biomarkers known to target or utilize UBXN2B in therapeutic contexts as of the latest data.

Other names

p37NSFL1 cofactor p37p97 cofactor p37UBX domain protein 2BUBXN2B