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UBX domain-containing protein 7 (UBXN7)
- Target
- UBXN7
- Molecular classification
- Other (Ubiquitin-binding adapter protein; not a classic enzyme, transporter, receptor, or transcription factor)
01
Overview
UBX domain-containing protein 7 (UBXN7) is a human ubiquitin-binding adapter protein that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the VCP/p97 segregase, thereby regulating the turnover of ubiquitinated substrate proteins. It functions within the ubiquitin-proteasome system, facilitating the degradation of target proteins and modulating cellular responses to proteotoxic stress. UBXN7 is localized primarily in the nucleoplasm and is part of the VCP-NPL4-UFD1 ATPase complex. Mutations in the UBXN7 gene have been associated with rare genetic disorders and may influence cancer-related pathways due to its regulatory role in protein degradation[1][3][8]. No drugs are currently known to target UBXN7 directly, and it is not a therapeutic target as of current scientific consensus.
- Other names
- UBXD7KIAA0794UBX domain protein 7mKIAA0794A630090P18RGD1306346
02
Mechanism of action
not applicable (no known drugs; acts as a protein-protein interaction adapter in ubiquitin-proteasome systems)
03
Biological functions
Ubiquitin-binding adapter activityProtein-protein interaction mediatorRegulation of proteasome-mediated, ubiquitin-dependent protein catabolic processesAdapter/linker between NEDD8-associated cullin ring ligases (CRLs) and VCP/p97 complex
04
Disease associations
Cancer (implicated through role in protein degradation and regulation of cellular stress responses)Inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1Immunodeficiency 46Potential roles in other disorders involving protein homeostasis
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