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UBX domain protein 8 (UBXN8)
- Target
- UBXN8
- Molecular classification
- Other (classified as a UBX domain-containing protein; protein cofactor, involved in protein homeostasis and degradation, not part of classic receptor, enzyme, transporter, ion channel, or transcription factor families)
01
Overview
UBX domain protein 8 (UBXN8) is a transmembrane protein localized to the endoplasmic reticulum (ER) membrane, where it acts as a cofactor for p97/VCP (valosin-containing protein). Through its UBX domain, it tethers p97 to the ER membrane, facilitating efficient ER-associated degradation (ERAD) of misfolded lumenal proteins—an important process in maintaining protein homeostasis. UBXN8 also displays ubiquitin-binding activity and may have a role in reproduction, although this function is less well characterized. While genetic variants have been linked to hereditary spastic paraplegia (SPG8), UBXN8 is not widely accepted as a direct drug target or biomarker.
- Other names
- UBXN8UBX domain-containing protein 8UBXD6REP8Rep-8 proteinReproduction 8 proteinUBX domain-containing protein 6D8S2298E
02
Mechanism of action
no drugs targeting this protein, thus mechanisms of action are undefined
03
Biological functions
Ubiquitin bindingEndoplasmic reticulum-associated degradation (ERAD) of misfolded proteinsProtein quality controlMay play a role in reproduction
04
Disease associations
Spastic paraplegia (Autosomal Dominant), specifically Spastic Paraplegia 8Other (possibly implicated in protein quality control-related diseases, but limited direct disease associations)
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