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UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
- Molecular classification
- Enzyme, Metalloamidase
01
Overview
LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase) is an essential zinc-dependent metalloamidase enzyme found in virtually all Gram-negative bacteria. It catalyzes the first committed step in the biosynthesis of lipid A, a critical component of lipopolysaccharides (LPS). Lipid A acts as an endotoxin and is vital for bacterial viability and pathogenicity. As it catalyzes an essential step unique to bacteria, LpxC is a target for novel antibiotics. Inhibitors disrupt bacterial growth by blocking lipid A synthesis.
02
Mechanism of action
Inhibition of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase activity, blocking lipid A synthesis.
03
Biological functions
Lipid A biosynthesisCell envelope integrity
04
Disease associations
Infection
05
Safety considerations
ToxicityResistance development
06
Interacting drugs
CHIR-090
1 more in the full profile.
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